High Prevalence of Hepatotoxicity on HIV Patients under TDF First Base

In this cross-sectional rent, our data demonstrate a high prevalence of hepatotoxicity 21.65% (225). Among 1039 HIV infected individuals, 8.2% (85) were on NVP ground regimen, 38.8% (403) were on EFV based regimen, 26.18% (272) were on PI based regimen and 9.8% (102) were on raltegravir based regimen of which only 2.4% experienced severe hepatotoxicity (n=25). This is in contrast with the preceding(prenominal) findings, as many previous studies conducted so far have report high prevalence of severe hepatotoxicity. For example a line of business conducted by Ferdinand et al., reported grade 4 hepatotoxicity in 7.9% unhurrieds 8, a retrospective consume conducted at Duke University Medical Center (DUMC) and Durham VA Medical Center (DVAMC) infectious Diseases Clinics have reported 10.7% incidence of severe hepatotoxicity 9. However, a recent study conducted on Ethiopian cohort have reported grade 3 and grade 4 hepatotoxicity among 1.84% of HIV infected patients 10. The reason wh y the higher(prenominal) incidence was found among other cohort studies might be our study excluded patient with HBV/HCV infection.Among the 225 patients, 12.31% of them were on first line prowess regimen. However SH among patient on first line ART was found to be reach in 1.82%, this is similar with the previous finding that, among those receiving first line ART 1.7% had SH. However many finding states that overall rate of SH was surrounded by (4.2% - 8.9%) 11-13.In attachment by analyzing further we found that SH was found to be higher in NVP (19.35%) than EFV (14.4%) based NNRTI, this is in line with the previous findings. The proportion of hepatotoxicity among HIV infected individuals is found to be 3.84%, 2.21%, 0.96% for patients who are ART nave, on PI based regimen and raltegravir based ... ...transformed for statistical depth psychology. CD4 T-cell measurement was performed using flowcytometer FC 500, (Beckman Coulter, Pasadena, CA, USA), superlative and AST level wer e measured in Olympus AU400 Chemistry analyzer (Beckman Coulter, Pasadena, CA, USA). Statistical analysisBaseline characters were recorded as median and interquartile range for continuous variables and as percentages for categorical variables. Differences in demographic characters between 4 groups were compared using Kruskal-Wallis bear witness for continuous variables and Pearson chi-square and Fishers exact test for categorical variables. clipping to event between the groups was compared using Kaplan-Meier estimates and log rank test. Association between the risk factors and hepatotoxicity was computed using Odds Ratios (ORs). All statistical analysis was performed in Vasserstats Statistical computation website.